Overview of MR Tissue Evaluation after Ablation

We have been looking at the MR appearance of tissue after thermal ablation and comparing it to histology. Our goal is to develop imaging tools that will demonstrate the physiologic state of the tissue after ablation. Early on, we looked at T2-weighted MRI in the brain, but found that there was a time delay that occurred before changes were visible on T2-weighted images. In addition, there were no apparent changes on T2-weighted MRI in prostate tissue following an ultrasound ablation. As a result, we turned to contrast enhanced (CE) MRI, diffusion-weighted MRI (DWI), and magnetization transfer (MT) imaging following both ultrasound and cryoblation in the prostate.

Relevant Publications

Chen L, Bouley D, Yuh E, D'Arceuil H, Butts K, Study of Focused Ultrasound Tissue Damage Using MRI and Histology, JMRI 1999; 10:146-153.

Chen J, Daniel BL, Diederich CJ, Bouley DM, van den Bosch MA, Kinsey AM, Sommer G, Butts Pauly KB, Monitoring prostate thermal therapy with diffusion-weighted MRI, Magn Reson Med, 2008 Jun; 59(6):1365-72.

Van den Bosch M, Josan S, Bouley D, Chen J, Rieke V, Butts Pauly K, Daniel BL, MRI-guided Percutaneous Cryoablation of the Prostate: In Vivo Imaging of Cryonecrosis with histologic correlation in an animal model, JVIR, 2009 Feb;20(2):252-8.

Josan S, Bouley D, van den Bosch M, Daniel B, Butts Pauly K, MRI-guided cryoablation - in vivo assessment of focal canine prostate cryolesions, JMRI, in press.

Holbrook A, Bouley D, Alley M, Daniel B, Diederich C, Sommer G, Butts Pauly K, In vivo assessment of canine prostate thermal ablations with magnetization transfer imaging. , ISMRM, Berlin Germany May 2007, p. 1143.

Holbrook A, Josan S, Bouley D, Daniel B, Butts Pauly K, Acute and Chronic Magnetization Transfer Ratio Observations in Canine Cryoablation, ISMRM, Toronto, May 2008 p. 1242.