Daniel M. Spielman

My research interests are in the field of magnetic resonance imaging and in vivo spectroscopy. Current projects include optimized mapping of metabolite distributions in the brain and acquisition and analyis of dynamic MRI for the assessment of kidney function. In our laboratory, we have focussed on an array of novel techniques for producing clinically valuable images of important metabolic chemicals (e.g., NAA, creatine, choline, and lactate). These techniques, which include improved spectroscopic imaging and shimming methods as well as the application of estimation theory for optimal data quantification, address the inherent difficulties of low concentrations of the desired components, overlapping resonances, and field inhomogeneities caused by imperfect magnets and magnetic susceptibility variations with the body. Applications of this work include cerebral stoke evaluation as well as cancer diagnosis, treatment monitoring, and prediction of response to therapy. In addition, we are conducting basic research into a variety of neurologic disorders including Alzheimer's disease, schizophrenia, and epilepsy.

Representative Publications

Nakai, T, Rhine, W, Enzmann, D, Stevenson, D, Spielman, D, "A Model for Detecting Early Metabolic Changes in Neonatal Asphyxia by 1H-MRS", Journal of Magnetic Resonance Imaging, 6:445-452, 1996.

Lim, K, Spielman, D, "Estimating NAA in Fully Volumed Cortical Gray Matter with Applications for Measuring Changes Due to Aging", Mag. Res. Med., 37:372-377,1996.

Blankenberg, F, Katsikis, P, Storrs, R, Beaulieu, C, Spielman, D, Chen, J, Naumovski, L, Tait, J, "Quantitative Analysis of Apoptotic Cell Death Using Proton Nuclear Magnetic Resonance Spectroscopy", Blood, 89(10):3778-86, 1997.

Morrell, G, Spielman, D, "Dynamic Shimming for Mutlislice MRI", Magn Res Med, 38:477-483, 1997.

Blankenberg, F., Loh, N., Alexander, M., Norbash, A., Craychee, J., Spielman, D., Person, B., Berg, C.A., Enzmann, D., "Impaired Cerebrovascular Autoregulation After Hypoxix-Ischemic Injury in Extremely Low Birthweight Neonates: Detection with Power and Pulsed Wave Doppler US", Radiology, 205(2):363-8, 1997.

E. Adalsteinsson, P. Irarrazabal, S. Topp, C. Meyer, A. Macovski, and D. Spielman, "Volumetric Spectroscopic Imaging with Spiral-Based k-Space Trajectories",Magnetic Resonance in Medicine. 39:889-898, 1998.

Star-Lack JM, Spielman DM, Adalsteinsson E, Kurhanewicz J, Terris DJ, and Vigneron DB, "In Vivo Lactate Editing with Simultaneous Detection of Choline, Creatine, NAA, and Lipid Singlets at 1.5 T Using PRESS Excitation with Applications to the Study of Brain and Head and Neck Tumors",J. Magn. Reson. 133(2):243-254, 1998.

Spielman D, Adalsteinsson E, Lim,K, "Quantitative Assessment of Improved Homogeneity Achievable Using Linear Versus Higher Order Shims for Spectroscopic Imaging of the Brain", Magn Res Med, 40(3):376-382, 1998.

Lim K, Adalsteinsson E, Spielman D, Sullivan E, Rosenbloom M, Pfefferbaum A, "Proton Magnetic Resonance Spectroscopic Imaging of Cortical Gray and White Matter in Schizophrenia", Arch Gen Psychiatry, 55(4):346-352, 1998.

A. Pfefferbaum, E. Adalsteinsson, D. Spielman, E. Sullivan, K. Lim, "In Vivo Spectroscopic Qunatification of N-acetyl aspartate, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging", Magn Reson Med. 1999 Feb;41(2):276-84.

Adalsteinsson, E, Spielman, D, Pauly, J, Terris, D, Sommer, G, Macovski, A, "A Feasibility Study of Lactate Imaging of Head and Neck Tumors", NMR in Biomedicine., 11(7):360-9, 1998.

Nakai, T, Rhine, W, Okada, T, Stevenson, D, Spielman, D, "Strategy of Lipid Suppression in Lactate Imaging Using STIR-DQCT: A Study of Hypoxic Ischemic Brain Injury", Magnetic Resonance in Medicine. 40:629-632, 1998.

Adalsteinsson, E, Spielman, D, "Spatially Resolved Two-Dimensional Spectroscopy", Magnetic Resonance in Medicine, 41:8-12, 1999.

Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan E, Lim K, "In vivo Brain Concentrations of N-aectyl compounds, creatine, and choline in Alzheimer's disease", Archives of General Psychiatry, 56(2): 185-92, 1999.

Adalsteinsson E, Star-Lack J, Meyer C, and Spielman D, "Reduced Spatial Side Lobes in Chemical Shift Imaging", Magnetic Resonance in Medicine, 42:314-323, 1999.

Star-Lack J, Adalsteinsson E, Adam M, Terris D, Pinto H, Brown JM, Spielman D, "In vivo 1H Spectroscopy of Human Head and Neck Tumors, with Comparison to Oxygen Tension Measurements", American Journal of Neuroradiology, 21(1): 183-93, 2000.

Winsberg M, Sachs N, Tate D, Adalsteinsson E, Spielman D, and Ketter T, "Decreased Dorsolateral Prefronal N-Acetyl Aspartate in Bipolar Disorder" Biological Psychiatry, 47(6):475-81, March 15, 2000.

Star-Lack J, Adalsteinsson E, Gold G, Spielman D, "Motion Correction and Lipid Suppression for 1H MRS of the Body", Magnetic Resonance in Medicine, 43:325-330, 2000.

Adalsteinsson E., Sullivan E., N. Kleinhans, Spielman D., Pfefferbaum A., "A Longitudinal Study of NAA in Alzheimer's Disease", Lancet, 355:1696, May 13th 2000.

Hanson L, Adalsteinsson E, Pfefferbaum A, and Spielman D, "Optimal Voxel Size for Gray and White Matter Spectroscopy", Magn Reson Med. 2000 July, 44(1): 10-8.

Sullivan EV, Adalsteinsson E, Spielman DM, Hurd RE, Pfefferbaum A. "N-acetylaspartate - A Marker of Neuronal Integrity". American Neurology, 2001 December, 50(6):823-825.

Star-Lack JM, Spielman DM. "Zero-quantum Filter Offering Single-shot Lipid Suppression and Simultaneous Detection of Lactate, Choline, and Creatine Resonances". Magnetic Resonance in Medicine, 46(6):1233-1237, 2001.

Thorton SJ, Spielman DM, Pelc NJ, Block WF, Crocker DE, Costa DP, LeBoeuf BJ, Hochachka PW. "Effects of Forced Diving on the Spleen and Hepatic Sinus in Northern Elephant Seal Pups". Proceedings of the National Academy of Science, 98(16):9413-9418, 2001.